The Grand Opera House was the name of two theatres located in St. Louis, Missouri on the same property on the south side of Market Street between Broadway and Sixth Streets. The first theatre, originally known as the Varieties Theatre, opened in 1852 and went by several different names, including the Grand Opera House, during its thirty-two year existence. After it was destroyed by fire in November 1884, a second theatre, known from its inauguration as the Grand Opera House, was built on the site of the first theatre and opened just 10 months after the destruction of the first theatre in September 1885. In 1935 the second Grand Opera House was renamed the Grand Theatre when it became part of a chain of a burlesque circuit of theaters. It operated under that name into the early 1960s. In 1963 the theatre was demolished to make room for Busch Memorial Stadium.